Journal: Journal of Nanobiotechnology
Article Title: Self-assembled copper-based nanoparticles for enzyme catalysis-enhanced chemodynamic/photodynamic/antiangiogenic tritherapy against hepatocellular carcinoma
doi: 10.1186/s12951-024-02626-x
Figure Lengend Snippet: Physicochemical properties of the TCCHA nanoparticles. ( A ) Fluorescence spectra of TPA solutions and ( B ) UV-vis spectra of MB solutions after incubation with pristine H 2 O 2 , TCCHA and H 2 O 2 /TCCHA mixed solutions. UV-vis spectra of MB solutions incubated with H 2 O 2 /TCCHA mixed solutions at ( C ) different time intervals and ( D ) different H 2 O 2 concentrations. ( E ) Changes in the dissolved oxygen concentration in pristine H 2 O 2 , TCCHA and H 2 O 2 /TCCHA mixed solutions. n = 3, *** p < 0.001. ( F ) Fluorescence intensities of the SOSG probe after incubation with Ce6 or TCCHA in the presence of H 2 O 2 under normoxic/hypoxic conditions before and after NIR laser irradiation. n = 3, ** p < 0.01. Cumulative release profiles of ( G ) Cu 2+ , ( H ) Ce6 and ( I ) AL3818 from TCCHA nanoparticles dispersed in different pH buffers (pH 7.4, pH 6.5, pH 5.0). n = 3, ** p < 0.01, *** p < 0.001
Article Snippet: A singlet oxygen sensor green (SOSG) fluorescent probe was obtained from Beyotime Biotechnology Co., Ltd. (Shanghai, China).
Techniques: Fluorescence, Incubation, Concentration Assay, Irradiation